Peritoneal Mesothelioma Information

Peritoneal mesothelioma is a malignancy that targets the lining of the abdomen. This form of cancer, like pleural mesothelioma, is mostly a result of exposure to asbestos. Peritoneal mesothelioma affects the lining that guards the abdomen's insides, and which also gives a lubricating fluid that facilitates the smooth movement and functioning of the organs.

This disease is also called diffuse peritoneal mesothelioma, particularly when the cancer has branched out. It accounts for about a tenth of all mesothelioma patients, and is the second most common after pleural mesothelioma.

There are a number of symptoms of this disease. Similar to other mesothelioma diseases, the latency period is long, and symptoms remain dormant for decades after initial exposure. By the time the symptoms become conspicuous, it may be too late. Furthermore, if your doctor is not aware of your previous exposure to asbestos, then he may treat you for different ailments.

The most common symptoms of peritoneal mesothelioma are weight loss; nausea; abdominal pains and weakness; lack of appetite; bowel obstruction; and abdominal swelling. Problems such as shortness of breath and extreme pain can also be experienced.

Treatment for this form of mesothelioma is dependent on a number of factors, such as the extent of the cancer and the patient's general health, age and past medical history.

Surgery is one conventional option of treating peritoneal mesothelioma. This involves taking out portions of the abdomen's lining in order to remove the tumor. Surgery also depends largely on the age of the patient and the extent to which the cancer has spread. Sometimes, it becomes imperative to take out a part of the diaphragm, so as to facilitate the easy removal of the tumor.

In radiation therapy, high-energy x-rays are deployed to shrink the size of the tumor or kill off malignant cells. Radiation therapy can be approached in two ways. One is the external method, where radiation is emitted through the body from a machine placed outside. The second method is by emitting radiation directly to the malignant area through plastic tubes.

Chemotherapy is doubtless the most common and well-known method of combating cancer. Here, a combination of drugs - through tablets or needles -- is used to kill malignant cells.

Mesothelioma Information [http://www.WetPluto.com/Mesothelioma-Information.html] provides detailed information on Mesothelioma Information, Mesothelioma Legal Information, Pleural Mesothelioma Information, Peritoneal Mesothelioma Information and more. Mesothelioma Information is affiliated with Clinical Mesothelioma Symptoms [http://www.e-mesotheliomasymptoms.com].

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Peritoneal Mesothelioma Cancer

The cancer of the lining of the abdominal cavity is called peritoneal mesothelioma. It is not as common as pleural form; it comprises an estimated one fifth to one third of all diagnosed mesothelioma cases. This report of the Surveillance, Epidemiology and End Results (SEER) approximates the number as 54.7% male and 45.3% female, with the age ranging from 65 to 69. The period of latency is shorter for patients exposed in asbestos, the symptoms appearing after 20 to 30 years from exposure; the usual latency period for pleural mesothelioma is 30 to 40 years.

Peritoneal Mesothelioma Symptoms

At the time of presentation, symptoms of peritoneal mesothelioma includes abdominal mass, abdominal pain, enlarged abdominal girth, fluid in the abdomen (ascites), distention of the abdomen, weight loss, fever, anemia, fatigue and digestive disturbances. For a few months before a confirmed diagnosis, some patients even complain of symptoms that are non-specific. Incidentally, peritoneal mesothelioma is found in a percentage of cases once the patient has other health complaints such as hernia, gallbladder or pelvic mass.

Doctors who have experiences in this field have noted that typically, patients have these symptoms six months to two years prior to the diagnosis. Men often come to the doctor complaining of a bulge in the groin (hernia) or around the belly button (umbilical hernia). For women, the first sign of a problem often occurs after a pelvic test when a tumor mass have been discovered.

In later stages of peritoneal mesothelioma, among the symptoms are increased occurrences of blood clots and obstruction of the bowel. There is a noticeable increase on the platelet count for 50% of peritoneal patients but this may be caused by various disorders, so this is actually of little help in the diagnosis. Low albumin level and anemia can also be among the symptoms.

Peritoneal Mesothelioma Diagnosis

Peritoneal mesothelioma has two clinical types which can be differentiated with the help of CT findings, the "dry" type and the "wet". It is classified as "dry" when there are multiple tiny masses or one dominant localized mass and generally little or no ascites. The "wet" type has widespread small nodules, no dominant mass and a presence of ascites.

If fluid is found, the process of eliminating it is through paracentesis; however the analysis of this fluid has limited diagnostic significance. Normally, a definitive diagnosis may be obtained through tissue biopsy.

Staging

As there is currently no staging system for peritoneal mesothelioma, the most popular system for general cancer staging (TNM system) is used. TNM system has the following criteria: (T) status of the tumor, (N) lymph nodes and (M) metastases. Other general categories may also be helpful in order to determine the stage.

Category 1 - with a localized lesion that can entirely be removed (resected)

Category 2 - the disease is located inside the abdominal cavity on peritoneal or organ surfaces where there is a probability of removing as much tumor as possible (debulking)

Category 3 - the disease is located inside the abdominal cavity and invades organs such as liver or colon.

Category 4 - the disease extends outside of the abdominal cavity

Peritoneal Mesothelioma Treatment

In the past years, the effectiveness of surgery alone or intraperitoneal chemotherapy in the treatment of peritoneal mesothelioma were not proven, that is why multimodality treatment is becoming more popular. Debulking (cytoreductive) surgery is removing all or nearly all visible tumors and may be combined with IPHC (Intra-Peritoneal Hyperthermic Chemotherapy), intraperitoneal chemotherapy and radiation.

Removing all tumors is not always probable; the prognosis for survival can then be in accordance with the completeness of cytoreduction which is established by these criteria:

• Complete cytoreduction

(CC-0): No peritoneal seeding is found within the operative areas

(CC-1): Nodules less than 2.5 cm carries on after cytoreduction which can be penetrated by intra-cavity chemotherapy; thus the process is termed complete.

• Incomplete cytoreduction

(CC-2) Nodules with sizes of 2.5 to 5 cm carry on after cytoreduction

(CC-3) Nodules that are larger than 5 cm are found; or there is a merging of tumor nodules that are unresectable at any area within the pelvis or abdomen.

Some patients may have widespread disease where surgery is not considered as "potentially curative", palliative treatment may be done by debulking. Take note that specialized treatments should only be administered by seasoned doctors because peritoneal mesothelioma is a rare malignant disease.

Recently, a clinical trial discovered Alimta (pemetrexed) to be effective as chemotherapy agent on treating peritoneal mesothelioma, either on its own or combined with cisplatin or any platinum-based drug. This reflects the previous findings regarding pemetrexed medication of pleural mesothelioma.

For more information on Peritoneal Mesothelioma or any other type of Mesothelioma Cancer a good information site is Mesothelioma Symptoms, where all releavant topics are discussed. Some example topics include Mesothelioma treatment, Mesothelioma Compensation, Mesothelioma statistics, coping with Mesothelioma and causes of Mesothelioma. A forum is also availble to discuss any topics with our experts.

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